Biocomposites composed of cartilage and natural rubber latex
نویسندگان
چکیده
We have successfully fabricated the cartilage/natural rubber latex (NRL) biocomposites via human mesenchymal stem cells (hMSCs) spheroid under hypoxic condition. It was revealed that NRL nanoparticles acted as main component, providing surface heterogeneity for spheroids and resulting in a mechanically stable structure with modulus two times higher compared to controls. The formation of cartilage/NRL biocomposite results having stiff property demonstrated. gene expression levels SRY-box 9 (SOX9), aggrecan type II collagen (Col-II), glycosaminoglycan’s were conditions, administration enhanced chondrogenic differentiation is induced. promise well-controlled cartilage tissue
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ژورنال
عنوان ژورنال: International physical medicine & rehabilitation journal
سال: 2023
ISSN: ['2574-9838']
DOI: https://doi.org/10.15406/ipmrj.2023.08.00331